Side effects of anticytokine strategies.
Publication year
2005Source
Netherlands Journal of Medicine, 63, 3, (2005), pp. 78-80ISSN
Publication type
Article / Letter to editor
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Organization
Internal Medicine
Journal title
Netherlands Journal of Medicine
Volume
vol. 63
Issue
iss. 3
Page start
p. 78
Page end
p. 80
Subject
EBP 3: Effective Primary Care and Public Health; N4i 1: Pathogenesis and modulation of inflammation; N4i 2: Invasive mycoses and compromised host; NCMLS 1: Infection and autoimmunity; UMCN 4.1: Microbial pathogenesis and host defenseAbstract
Anticytokine strategies probably represent the most important breakthrough in the treatment of inflammatory diseases in the last decade. However, blocking the bioactivity of proinflammatory cytokines, crucial activators of host defence, has proved to be accompanied by an increased susceptibility to infections, especially with Mycobacteria, Salmonellae and fungal pathogens. Multiple mechanisms for these side effects have been proposed, such as inhibition of gamma-interferon production, decreased expression of pattern-recognition receptors, and leucocyte apoptosis. Caution is therefore warranted when these treatments are given to patients with an increased risk for infections. A range of side effects other than infection have been reported.
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- Academic publications [238441]
- Electronic publications [122523]
- Faculty of Medical Sciences [90373]
- Open Access publications [97518]
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