Sodium sieving in children.
SourcePeritoneal Dialysis International, 25 Suppl 3, supplement 3, (2005), pp. S141-2
Article / Letter to editor
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Peritoneal Dialysis International
vol. 25 Suppl 3
iss. supplement 3
SubjectIGMD 9: Renal disorder; UMCN 5.4: Renal disorders
Sodium sieving is a consequence of dissociation between the amount of water and sodium transported over the peritoneal membrane. This dissociation occurs in the presence of aquaporin-mediated water transport. Sieving of sodium can be used as a rough measure for aquaporin-mediated water transport. Icodextrin contains glucose polymers, inducing ultrafiltration by colloid osmosis. Therefore, aquaporins play a minor role in ultrafiltration, which is confirmed by the absence of sodium sieving. Icodextrin is very suitable for the daytime dwell in children on a nightly intermittent peritoneal dialysis regimen. Ultrafiltration obtained with icodextrin is similar to ultrafiltration obtained with 3.86% glucose after a 12-hour dwell. When using icodextrin in children, it is also confirmed by the absence of sodium sieving that the aquaporins play a minor role in ultrafiltration.
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