Gray matter volume reduction in the chronic fatigue syndrome.
Publication year
2005Source
NeuroImage, 26, 3, (2005), pp. 777-81ISSN
Publication type
Article / Letter to editor
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Organization
Donders Centre for Cognitive Neuroimaging
Medical Psychology
SW OZ DCC CO
Internal Medicine
Former Organization
F.C. Donders Centre for Cognitive Neuroimaging
SW OZ NICI CO
Journal title
NeuroImage
Volume
vol. 26
Issue
iss. 3
Page start
p. 777
Page end
p. 81
Subject
111 000 Intention & Action; 111 002 Neural dynamics of movement representations; EBP 1: Determinants of Health and Disease; EBP 3: Effective Primary Care and Public Health; N4i 1: Pathogenesis and modulation of inflammation; N4i 2: Invasive mycoses and compromised host; NCEBP 10: Human Movement & Fatigue; NCEBP 8: Psychological determinants of chronic illness; NCMLS 1: Infection and autoimmunity; ONCOL 4: Quality of Care; UMCN 4.1: Microbial pathogenesis and host defense; UMCN 4.2: Chronic inflammation and autoimmunityAbstract
The chronic fatigue syndrome (CFS) is a disabling disorder of unknown etiology. The symptornatology of CFS (central fatigue, impaired concentration, attention and memory) suggests that this disorder could be related to alterations at the level of the central nervous system. In this study, we have used an automated and unbiased morphometric technique to test whether CFS patients display structural cerebral abnormalities. We mapped structural cerebral morphology and volume in two cohorts of CFS patients (in total 28 patients) and healthy controls (in total 28 controls) from high-resolution structural magnetic resonance images, using voxel-based morphometry. Additionally, we recorded physical activity levels to explore the relation between severity of CFS symptoms and cerebral abnormalities. We observed significant reductions in global gray matter volume in both cohorts of CFS patients, as compared to matched control participants. Moreover, the decline in gray matter volume was linked to the reduction in physical activity, a core aspect of CFS. These findings suggest that the central nervous system plays a key role in the pathophysiology of CFS and point to a new objective and quantitative tool for clinical diagnosis of this disabling disorder.
This item appears in the following Collection(s)
- Academic publications [245131]
- Donders Centre for Cognitive Neuroimaging [4021]
- Electronic publications [132445]
- Faculty of Medical Sciences [93207]
- Faculty of Social Sciences [30338]
- Open Access publications [106003]
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