CSF levels of angiogenesis-related proteins in patients with leptomeningeal metastases.
until further notice
SourceNeurology, 65, 7, (2005), pp. 1120-2
Article / Letter to editor
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SubjectUMCN 5.2: Endocrinology and reproduction
The authors determined the levels of vascular endothelial growth factor (VEGF) and urokinase-type plasminogen activator (uPA) in the CSF of patients with leptomeningeal metastases (LM; n = 53), cancer patients without LM (n = 18), and subjects without malignancy (n = 25). Median levels of uPA and VEGF were significantly higher in patients with LM, supporting the hypothesis that angiogenesis contributes to LM. VEGF was negatively correlated with survival in patients with LM, suggesting its use as a prognostic factor.
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