Nutrition and genes in the development of orofacial clefting.
SourceNutrition Reviews . New York, 64, 6, (2006), pp. 280-288
Article / Letter to editor
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Theorie van religie, moraal en cultuur
Epidemiology, Biostatistics & HTA
Religie- en cultuurtheorie
Nutrition Reviews . New York
SubjectEBP 1: Determinants in Health and Disease; UMCN 5.1: Genetic defects of metabolism; UMCN 5.2: Endocrinology and reproduction
Clefts of the lip, alveolus, and/or palate, which are called orofacial clefts (OFC), occur in 0.5 to 3 per 1000 live and stillbirths. The pathogenesis of these congenital malformations remains largely unknown, but evidence is increasing that both nutritional and genetic factors are involved. Unlike genetic factors, nutritional causes can be corrected and may therefore contribute to the prevention of OFC. The goal of this review is to summarize the embryogenesis and genes involved in OFC, and to give an overview of the nutrients and related genes in humans. Improving our knowledge of the role of nutrition, genes, and their interactions in the pathogenesis of OFC may stimulate the development of nutritional interventions for OFC prevention in the future.
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