Chemical synthesis of picornaviral protein primers of RNA replication
SourceOrganic & Biomolecular Chemistry, 4, 19, (2006), pp. 3576-3586
Article / Letter to editor
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Physical Chemistry/Biophysical Chemistry
Organic & Biomolecular Chemistry
Naturally occurring nucleopeptidic replication primers (VPg-pUpU) of poliovirus and coxsackie virus were chemically synthesized. The synthesis was accomplished via block-coupling of two minimally protected fragments of the target structures: a short RNA-nucleopeptide and a longer peptide segment containing diverse side-chain functionalities. The synthetic VPg-pUpU of coxsackie virus was characterized by NMR spectroscopy.
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