Real-time trace gas sensing of ethylene, propanal and acetaldehyde from human skin in vivo.
until further notice
SourcePhysiological Measurement, 27, 11, (2006), pp. 1187-1196
Article / Letter to editor
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Molecular and Laser Physics
Epidemiology, Biostatistics & HTA
SubjectEBP 1: Determinants in Health and Disease; Molecular and Laser Physics; NCEBP 1: Molecular epidemiology; UMCN 1.5: Interventional oncology
Trace gases emitted by human skin in vivo are monitored non-invasively and in real time using laser-based photoacoustic detection and proton-transfer reaction mass spectrometry. A small quartz cuvette is placed on the skin to create a headspace from which a carrier gas transports the skin emissions to the detection systems. The transparency of quartz to ultraviolet radiation (UVR) allows investigation of UVR-related trace gas emissions. As a demonstration of this measurement system, the effect of supplemental intake of systemic antioxidants on UVR-induced lipid peroxidation is investigated. The production by the skin of three biomarkers of UVR-induced lipid peroxidation (ethylene, acetaldehyde and propanal) is monitored. Although no significant effect of antioxidant intake was observed, the method presented here is a novel and promising technique for investigation of human skin in vivo.
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