Hysteresis and bistability in a realistic cell model for calcium oscillations and action potential firing.
SourcePhysical Review Letters, 98, 9, (2007), pp. 098107
Article / Letter to editor
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Medical Physics and Biophysics
Radboud University Nijmegen Medical Centre
Physical Review Letters
SubjectBiophysics; Cell Biology; DCN 1: Perception and Action; DCN 3: Neuroinformatics; NCMLS 7: Chemical and physical biology; UMCN 3.2: Cognitive neurosciences
Many cells reveal oscillatory behavior. Some cells reveal action-potential firing resulting from Hodgkin-Huxley (HH) type dynamics of ion channels in the cell membrane. Another type of oscillation relates to periodic inositol triphospate (IP3)-mediated calcium transients in the cytosol. In this study we present a bifurcation analysis of a cell with an excitable membrane and an IP3-mediated intracellular calcium oscillator. With IP3 concentration as a control parameter the model reveals a complex, rich spectrum of both stable and unstable solutions with hysteresis corresponding to experimental data. Our results reveal the emergence of complex behavior due to interactions between subcomponents with a relatively simple dynamical behavior.
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