High specificity of myositis specific autoantibodies for myositis compared with other neuromuscular disorders.
until further notice
SourceJournal of Neurology, 252, 5, (2005), pp. 534-537
Article / Letter to editor
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Epidemiology, Biostatistics & HTA
Journal of Neurology
SubjectBio-Molecular Chemistry; DCN 1: Perception and Action; DCN 2: Functional Neurogenomics; EBP 2: Effective Hospital Care; NCEBP 10: Human Movement & Fatigue; NCEBP 2: Evaluation of complex medical interventions; UMCN 1.5: Interventional oncology; UMCN 3.1: Neuromuscular development and genetic disorders; EBP 2: Effective Hospital Care; NCEBP 10: Human Movement & Fatigue
Myositis specific autoantibodies (MSAs) are proven to be specific for myositis compared with other inflammatory connective tissue diseases. Their specificity compared, however, with other neuromuscular disorders, which are included in the differential diagnosis of patients in whom the diagnosis myositis is under consideration, is unknown. We prospectively screened sera from 107 patients with various neuromuscular disorders for the most common MSAs and compared the results with the findings in a group of 97 myositis patients, published previously. Special attention was paid to patients with facioscapulohumeral muscular dystrophy (FSHD), an autosomal dominant muscle disease with marked inflammation in skeletal muscle tissue.Only one patient in the neuromuscular disorders group tested positive for an MSA, compared with 41 in the myositis group, resulting in a specificity of 99%. None of the FSHD patients tested positive. We conclude that the tested MSAs are highly specific for myositis and that they are not merely associated with muscle inflammation.
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