Citrullination of central nervous system proteins during the development of experimental autoimmune encephalomyelitis.
Publication year
2005Source
Journal of Comparative Neurology, 486, 3, (2005), pp. 243-253ISSN
Publication type
Article / Letter to editor

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Organization
Biomolecular Chemistry
Pathology
Journal title
Journal of Comparative Neurology
Volume
vol. 486
Issue
iss. 3
Page start
p. 243
Page end
p. 253
Subject
Bio-Molecular Chemistry; NCMLS 3: Tissue engineering and pathology; NCMLS 7: Chemical and physical biology; ONCOL 3: Translational research; UMCN 4.2: Chronic inflammation and autoimmunityAbstract
Immunization of mammals with central nervous system (CNS)-derived proteins or peptides induces experimental autoimmune encephalomyelitis (EAE), a disease resembling the human autoimmune disease multiple sclerosis (MS). Both diseases are accompanied by destruction of a part of the of the myelin sheaths, which surround neurites in the CNS. Previous studies in MS have described alterations in the citrullination of myelin basic protein, one of the main protein constituents of the myelin sheath. Here, we show that, also during the development of EAE in mice, hypercitrullination occurs in the areas of the spinal cord that show the highest degree of inflammation and that myelin basic protein and glial fibrillary acidic protein are among the hypercitrullinated proteins. We conclude that hypercitrullination of myelin proteins in the CNS is a common phenomenon in demyelinating disease. Hypercitrullination may cause conformational changes in proteins, so the affected proteins may be involved in the pathogenesis of CNS autoimmune disease by acting as autoreactive T-cell epitopes. This is the first report in which hypercitrullination of CNS proteins in EAE is described and in which proteins other than myelin basic protein are reported to be citrullinated during autoimmune-mediated CNS inflammation.
This item appears in the following Collection(s)
- Academic publications [204980]
- Faculty of Medical Sciences [81051]
- Faculty of Science [32345]
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