Lung Nodule Management in Low-Dose CT Screening for Lung Cancer: Lessons from the NELSON Trial.
Fulltext:
311679.pdf
Embargo:
until further notice
Size:
1.138Mb
Format:
PDF
Description:
Publisher’s version
Publication year
2024Source
Radiology, 313, 1, (2024), pp. e240535, article e240535ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Medical Imaging
Journal title
Radiology
Volume
vol. 313
Issue
iss. 1
Page start
p. e240535
Subject
Medical Imaging - Radboud University Medical CenterAbstract
Screening with low-dose CT (LDCT) in a high-risk population, as defined by age and smoking behavior, reduces lung cancer-related mortality. However, LDCT screening presents a major challenge. Numerous, mostly benign, nodules are seen in the lungs during screening. The question is how to distinguish the malignant from the benign nodules. Various studies use different protocols for nodule management. The Dutch-Belgian NELSON (Nederlands-Leuvens Longkanker Screenings Onderzoek) trial, the largest European lung cancer screening trial, used distinctions based on nodule volumetric assessment and growth rate. This review discusses key findings from the NELSON study regarding the characteristics of screening-detected nodules, including nodule size and its volumetric assessment, growth rate, subtype, and their associated malignancy risk. These results are compared with findings from other screening studies and current recommendations for lung nodule management. By examining differences in nodule management strategies and providing a comprehensive overview of outcomes specific to lung cancer screening, this review aims to contribute to the broader discussion on optimizing lung nodule management in screening programs.
This item appears in the following Collection(s)
- Academic publications [245262]
- Electronic publications [132642]
- Faculty of Medical Sciences [93207]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.