Effects of a combined exercise and dietary intervention on body composition, physical functioning and fatigue in patients with ovarian cancer: results of the PADOVA trial.
Fulltext:
308558.pdf
Embargo:
until further notice
Size:
443.5Kb
Format:
PDF
Description:
Publisher’s version
Publication year
2024Source
British Journal of Cancer, 131, 1, (2024), pp. 101-109ISSN
Annotation
01 juli 2024
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Medical Biosciences
Physiology
Gynaecology
Medical Oncology
Journal title
British Journal of Cancer
Volume
vol. 131
Issue
iss. 1
Page start
p. 101
Page end
p. 109
Subject
Gynaecology - Radboud University Medical Center; Medical Biosciences - Radboud University Medical Center; Medical Oncology - Radboud University Medical CenterAbstract
BACKGROUND: Guidelines recommend to include exercise and dietary advice in standard care for patients with cancer, based on evidence primarily derived from patients with breast cancer. Its applicability to patients with ovarian cancer is uncertain due to differences in patient characteristics and treatments. The PADOVA trial examined the effectiveness of a combined exercise and dietary intervention on fat-free mass (FFM), physical functioning, and fatigue. METHODS: In total, 81 patients with ovarian cancer were randomised to the exercise and dietary intervention (n = 40) or control (n = 41) group. Measurements were performed before chemotherapy, after chemotherapy, and 12 weeks later. FFM was assessed by bioelectrical impedance analysis, and physical functioning and fatigue were assessed using questionnaires. Intervention effects were assessed on an intention-to-treat basis using linear mixed models. RESULTS: FFM and physical functioning increased, and fatigue decreased significantly over time in both groups. No significant difference between the groups were found for FFM (β = -0.5 kg; 95% CI = -3.2; 2.1), physical functioning (β = 1.4; 95% CI = -5.4; 8.3) and fatigue (β = 0.7; 95% CI = -1.5; 2.8). CONCLUSIONS: During treatment, both groups improved in FFM, physical functioning, and fatigue. The intervention group, however, did not demonstrate additional benefits compared to the control group. This highlights the need for caution when extrapolating findings from different cancer populations to patients with ovarian cancer.
This item appears in the following Collection(s)
- Academic publications [245186]
- Electronic publications [132491]
- Faculty of Medical Sciences [93207]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.