Targeting phagocytic cells to overcome tumor immune suppression using tailored polymeric nanoparticles
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Publisher’s version
Publication year
2024Author(s)
Publisher
S.l. : s.n.
ISBN
9789465061627
Number of pages
181 p.
Annotation
Radboud University, 23 september 2024
Promotor : Vries, I.J.M. de Co-promotores : Fauerbach, Jonathan A.A., Flórez-Grau, G.
Publication type
Dissertation
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Organization
Tumorimmunology
Subject
Medical Biosciences - Radboud University Medical CenterAbstract
Cancer can create an environment that suppresses the immune response, helping tumors grow. Immunotherapy aims to activate the immune system against tumors, but it faces challenges like immune suppression. One suppressive factor is tumor-derived prostaglandin E2 (PGE2), which suppresses various immune cells. PGE2 signals through two receptors, called EP2 and EP4. Previous research found inhibiting PGE2 signaling by blocking EP2 and EP4 receptors with antagonists can boost the immune response. This thesis explores the use of nanoparticles to deliver EP2 and EP4 antagonists to immune cells. Nanoparticles containing these antagonists were developed and taken up by immune cells like dendritic cells and neutrophils. The nanoparticles successfully prevented the immune suppression caused by tumor fluids containing PGE2 in these cells. Highlighting the potential of blocking PGE2 signaling with nanoparticles containing EP2 and EP4 antagonists to enhance cancer therapy by improving immune cell function.
This item appears in the following Collection(s)
- Academic publications [245050]
- Dissertations [13773]
- Electronic publications [132309]
- Faculty of Medical Sciences [93209]
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