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Publication year
2024Source
Critical Reviews in Oncology Hematology, 199, (2024), pp. 104381, article 104381ISSN
Annotation
01 juli 2024
Publication type
Article / Letter to editor
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Organization
Radiation Oncology
Journal title
Critical Reviews in Oncology Hematology
Volume
vol. 199
Page start
p. 104381
Subject
Radiation Oncology - Radboud University Medical CenterAbstract
INTRODUCTION AND PURPOSE: With a significant global impact, treatment of gastrointestinal (GI) cancers still presents with challenges, despite current multimodality approaches in advanced stages. Clinical trials are expanding for checkpoint inhibition (ICI) combined with radiation therapy (RT). This review intends to offer a comprehensive image of the current data regarding the effectiveness of this association, and to reflect on possible directions to further optimize the results. RESULTS: Several early phase studies demonstrated encouraging potential. However, translating preclinical outcomes to clinical settings proves challenging, especially in immunologically "cold" environments. GI cancers exhibit heterogeneity, requiring tailored approaches based on disease stage and patient characteristics. Current results, though promising, lack the power of evidence to influence the general practice. CONCLUSIONS: Finding biomarkers for identifying or converting resistant cancers is essential for maximizing responses, moreover in this context strategic RT parameters need to be carefully considered. Our review emphasizes the significance of having a thorough grasp of how immunology, tumour biology, and treatment settings interact in order to propose novel research avenues and efficient GI cancer therapy.
This item appears in the following Collection(s)
- Academic publications [245131]
- Electronic publications [132465]
- Faculty of Medical Sciences [93207]
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