Impact of hyperaemic stenosis resistance on long-term outcomes of stable angina in the ILIAS Registry.
Fulltext:
307614.pdf
Embargo:
until further notice
Size:
1023.Kb
Format:
PDF
Description:
Publisher’s version
Publication year
2024Author(s)
Source
Eurointervention, 20, 11, (2024), pp. e699-e706ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Cardiology
Journal title
Eurointervention
Volume
vol. 20
Issue
iss. 11
Page start
p. e699
Page end
p. e706
Subject
Cardiology - Radboud University Medical CenterAbstract
BACKGROUND: The hyperaemic stenosis resistance (HSR) index was introduced to provide a more comprehensive indicator of the haemodynamic severity of a coronary lesion. HSR combines both the pressure drop across a lesion and the flow through it. As such, HSR overcomes the limitations of the more traditional fractional flow reserve (FFR) or coronary flow reserve (CFR) indices. AIMS: We aimed to identify the diagnostic and prognostic value of HSR and evaluate the clinical implications. METHODS: Patients with chronic coronary syndromes (CCS) and obstructive coronary artery disease were selected from the multicentre ILIAS Registry. For this study, only patients with combined Doppler flow and pressure measurements were included. RESULTS: A total of 853 patients with 1,107 vessels were included. HSR more accurately identified the presence of inducible ischaemia compared to FFR and CFR (area under the curve 0.71 vs 0.66 and 0.62, respectively; p<0.005 for both). An abnormal HSR measurement was an independent and important predictor of target vessel failure at 5-year follow-up (hazard ratio 3.80, 95% confidence interval: 2.12-6.73; p<0.005). In vessels deferred from revascularisation, HSR seems to identify more accurately those vessels that may benefit from revascularisation rather than FFR and/or CFR. CONCLUSIONS: The present study affirms the theoretical advantages of the HSR index for the detection of ischaemia-Âinducing coronary lesions in a large CCS population. (Inclusive Invasive Physiological Assessment in Angina Syndromes Registry [ILIAS Registry], ClinicalTrials.gov: NCT04485234).
This item appears in the following Collection(s)
- Academic publications [245262]
- Electronic publications [132642]
- Faculty of Medical Sciences [93207]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.