The wondrous world of glycobiology: Using sugar mimetics as potential anti-cancer therapy = De wondere wereld van glycobiologie: Het gebruik van aangepaste suikers als mogelijke anti-kanker therapie
Annotation
Radboud University, 25 juni 2024
Promotor : Rutjes, F.P.J.T. Co-promotores : Boltje, T.J., Büll, C.
Publication type
Dissertation
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Organization
Synthetic Organic Chemistry
Languages used
English (eng)
Subject
Synthetic Organic ChemistryAbstract
Sugars are essential building blocks of life that can form complex structures with many biological functions. In cancer, changes in these sugar structures are commonly found as a global, tumor promoting mechanism. Two often studied changes involve sugar building blocks sialic acid and fucose. Small alterations of these sugars can result in great research tools to study specific sugar-related processes and their effects. For example inhibitors can be made that can block the incorporation of these sugars into sugar structures. Therefore, this PhD mainly focused on sialic acid and fucose, and the use of modified forms of these sugars in the context of cancer therapy. We reviewed the current knowledge on O-acetylated sialic acids in health and disease and implications for future inhibitors. In addition, we made an overview of currently known sugar inhibitors and their use as cancer therapeutics. Furthermore we investigated the metabolic processing of modified sialic acids and developed novel modified fucoses that act as inhibitors. Next we further explored their potential use in cancer therapy in prostate and endometrial cancer. We anticipate our findings will lead to the broader use of these inhibitors to explore the role of these sugars in tumor pathology and may pave the way for the development of new therapies.
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- Academic publications [245131]
- Dissertations [13779]
- Electronic publications [132467]
- Faculty of Science [37407]
- Open Access publications [106059]
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