The urothelial barrier in interstitial cystitis/bladder pain syndrome: its form and function, an overview of preclinical models.
Publication year
2024Source
Current Opinion in Urology, 34, 2, (2024), pp. 77-83ISSN
Publication type
Article / Letter to editor
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Organization
Urology
Journal title
Current Opinion in Urology
Volume
vol. 34
Issue
iss. 2
Page start
p. 77
Page end
p. 83
Subject
Urology - Radboud University Medical CenterAbstract
PURPOSE OF REVIEW: Investigating bladder pain syndrome/interstitial cystitis (IC/BPS) preclinically is challenging. Various research models have been used to mimic the urothelial barrier closely and replicate the disease. The aim of this review is to discuss preclinical research related to the urothelial barrier in context of IC/BPS. RECENT FINDINGS: In vivo models mimic IC/BPS mainly with toxic substances in the urine, with protaminesulfate and proteoglycan deglycolysation resembling a temporary impaired barrier as seen in IC/BPS. This temporary increased permeability has also been found in vitro models. Glycosaminoglycan replenishment therapy has been described, in vivo and in vitro, to protect and enhance recover properties of the urothelium. The roles of immune and neurogenic factors in the pathogenesis of IC/BPS remains relatively understudied. SUMMARY: Preclinical studies provide opportunities to identify the involvement of specific pathologic pathways in IC/BPS. For further research is warranted to elucidate the primary or secondary role of permeability, together with inflammatory and neurogenic causes of the disease.
This item appears in the following Collection(s)
- Academic publications [245262]
- Electronic publications [132642]
- Faculty of Medical Sciences [93207]
- Open Access publications [106238]
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