Seasonal variation of anti-PD-1 outcome in melanoma-Results from a Dutch patient cohort.
Publication year
2024Author(s)
Source
Pigment Cell & Melanoma Research, 37, 1, (2024), pp. 15-20ISSN
Annotation
01 januari 2024
Publication type
Article / Letter to editor
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Organization
Medical Oncology
Journal title
Pigment Cell & Melanoma Research
Volume
vol. 37
Issue
iss. 1
Page start
p. 15
Page end
p. 20
Subject
Medical Oncology - Radboud University Medical CenterAbstract
Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment.
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- Academic publications [245186]
- Electronic publications [132505]
- Faculty of Medical Sciences [93207]
- Open Access publications [106090]
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