Protein aggregation in biomolecular condensates

Abstract

Protein aggregation, related to multiple neurodegenerative disorders, has been a topic of notable scientific interest for decades. However, only recently it has become clear that the aggregation process can be affected by another biologically important phenomenon - liquid-liquid phase separation, which underlies the formation of membraneless organelles. In this work, we investigate how the aggregation of proteins and peptides can be altered by the presence of biomolecular condensates by using simulations and experimental models in vitro.