High Variability in Isavuconazole Unbound Fraction in Clinical Practice: A Call to Reconsider Pharmacokinetic/Pharmacodynamic Targets and Breakpoints.
Publication year
2023Source
Clinical Pharmacokinetics, 62, 12, (2023), pp. 1695-1699ISSN
Annotation
01 december 2023
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Clinical Pharmacy
Medical Microbiology
Journal title
Clinical Pharmacokinetics
Volume
vol. 62
Issue
iss. 12
Page start
p. 1695
Page end
p. 1699
Subject
Radboudumc 4: lnfectious Diseases and Global Health Clinical Pharmacy; Radboudumc 4: lnfectious Diseases and Global Health Medical Microbiology; Radboudumc 9: Rare cancers Clinical Pharmacy; Radboud University Medical CenterAbstract
Isavuconazole exposure-response relationships have been studied with a focus on total rather than unbound exposure, assuming a constant unbound fraction of 1%. We observed a median (range) unbound fraction of 1.59% (0.42-5.30%) in patients. This highly variable protein binding asks for re-evaluation of current pharmacokinetic and pharmacodynamic targets for isavuconazole.
This item appears in the following Collection(s)
- Academic publications [245263]
- Electronic publications [132514]
- Faculty of Medical Sciences [93208]
- Open Access publications [106157]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.