Invasive Bladder Carcinoma Prognostic Assessment and Therapeutic Management.
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[S.l. : s.n.]
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RU Radboud Universiteit Nijmegen, 26 september 2006
Promotores : Witjes, J.A., Kiemeney, L.A.L.M.
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SubjectNCEBP 1: Molecular epidemiology; UMCN 1.2: Molecular diagnosis, prognosis and monitoring
The aims of this thesis can be summarized as follows: 1. To study the difference in prognosis between muscle-invasive bladder cancer patients with and without a history of superficial bladder cancer. 2. To determine the prognostic value of cell cycle regulatory proteins (p53, p27Kip1) and cell adhesion complex protein (a-catenin) in progressive bladder carcinoma.3. To evaluate the prognostic value of perineural and angiolymphatic invasion in advanced non-metastasized bladder cancer.4. To compare urodynamic and continence parameters between orthotopic sigmoid and ileal neobladder. 5. To investigate the effect of N-acetyl-L-cysteine (Fluimucil©) on the viscosity of ileal neobladder mucus. 6. To evaluate chemotherapy efficacy with Magnetic Resonance Imaging in patients with regionally metastatic or unresectable carcinoma of the bladder and 7. To review the use of imaging modalities in the assessment of bladder cancer stage.
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