The association between wearable device metrics and clinical outcomes in oncology: A systematic review with evidence synthesis and meta-analysis.
SourceCritical Reviews in Oncology Hematology, 185, (2023), article 103979
Article / Letter to editor
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Critical Reviews in Oncology Hematology
SubjectAll institutes and research themes of the Radboud University Medical Center; Radboudumc 14: Tumours of the digestive tract Physiology; Radboudumc 16: Vascular damage Physiology; Radboudumc 6: Metabolic Disorders Physiology
BACKGROUND: The emerging study of wearable devices (WDs) in patients with cancer provides opportunities to harness real-time patient data for predicting clinical outcomes. We conducted a systematic review with best evidence synthesis to examine the association between WD metrics and clinical outcomes in patients with cancer. METHODS: MEDLINE and Embase were searched from inception until June 2022. Risk of bias assessment and best evidence synthesis were performed and, If possible, meta-analysis was conducted. RESULTS: A total of 34 studies was included. We found moderate-to-strong evidence for associations between circadian rest-activity metrics and OS. Disrupted I<O was associated with increased hazard for death (HR 2.08; 95 %CI: 1.50-2.88). For most associations there was insufficient evidence due to lack of studies (n = 32) or inconsistent results (n = 14). CONCLUSION: Meta-analysis was greatly hampered due to heterogeneity and different methodology used between studies. Studies primarily designed to investigate the association between WD metrics and clinical outcomes are warranted.
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