Connectomic comparison of the human and non-human primate cortex to mouse
S.l. : s.n.
Donders Series ; 587
Number of pages
Radboud University, 07 februari 2023
Promotor : Helmstädter, M.N. Co-promotor : Hua, Y.
Display more detailsDisplay less details
SubjectDonders Series; Neurophysiology
Is the human brain simply a scaled-up version of the mouse brain? Sahil Loomba investigated the comparative aspects of structural connectivity in human, monkey and mouse brain using relatively novel three-dimensional electron microscopy technique. Sahil found evidence that the human nerve cells are composed of an increased number of interneurons that is two- to- three times higher compared to mouse. This, in effect, results in a massively increased connectivity between the inhibitory interneurons that is nearly absent in mouse. This, for the first time, points to a network innovation that is unique to the human cortical networks. This discovery encourages a new focus of studies on the functional relevance and impact of such connectivity features, with significance for fundamental as well as clinical neuroscience.
This item appears in the following Collection(s)
- Dissertations 
- Non RU Publications 
- Open Access publications 
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.