Treatment of fungal infections in surgical patients using conventional antifungals.
SourceJournal of Chemotherapy, 11, 6, (1999), pp. 494-503
Article / Letter to editor
Display more detailsDisplay less details
Blood Transfusion and Transplantation Immunology
Journal of Chemotherapy
SubjectThe role of cytokines in the pathophysiology of febrile illnesses and in host defense against infections; De rol van cytokinen in de pathofysiologie van koortsende ziekten en in de afweer tegen infecties
In surgical and intensive care units an alarming increase in the number of invasive fungal infections has been observed. This is partly due to temporal transferral of patients from hemato-oncological units or transplant units and partly to the enhanced use of corticosteroids and other immunosuppressants. Candida species have now become a common isolate in ill patients. Amphotericin B with or without flucytosine constituted the standard therapy for candidosis but similar response rates with less toxicity may be obtained with lipid and with fluconazole. Data on an improved outcome of candidemia if a central venous catheter is removed promptly are conflicting. Amphotericin B remains the standard therapy for other invasive mycoses; it is seldom possible to administer adequate doses and therefore the options and limitations of the triazoles and liposomal preparations should be explored.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.