The relationship between dose and serotonin transporter occupancy of antidepressants-a systematic review
Publication year
2022Source
Molecular Psychiatry, 27, 1, (2022), pp. 192-201ISSN
Publication type
Article / Letter to editor
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Organization
Psychiatry
Journal title
Molecular Psychiatry
Volume
vol. 27
Issue
iss. 1
Page start
p. 192
Page end
p. 201
Subject
Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience; Psychiatry - Radboud University Medical CenterAbstract
Brain imaging techniques enable the visualization of serotonin transporter (SERT) occupancy as a measure of the proportion of SERT blocked by an antidepressant at a given dose. We aimed to systematically review the evidence on the relationship between antidepressant dose and SERT occupancy. We searched PubMed and Embase (last search 20 May 2021) for human in vivo, within-subject PET, or SPECT studies measuring SERT occupancy at any dose of any antidepressant with highly selective radioligands ([(11)C]-DASB, [(123)I]-ADAM, and [(11)C]-MADAM). We summarized and visualized the dose-occupancy relationship for antidepressants across studies, overlaying the plots with a curve based on predicted values of a standard 2-parameter Michaelis-Menten model fitted using the observed data. We included seventeen studies of 10 different SSRIs, SNRIs, and serotonin modulators comprising a total of 294 participants, involving 309 unique occupancy measures. Overall, following the Michaelis-Menten equation, SERT occupancy increased with a higher dose in a hyperbolic relationship, with occupancy increasing rapidly at lower doses and reaching a plateau at approximately 80% at the usual minimum recommended dose. All the studies were small, only a few investigated the same antidepressant, dose, and brain region, and few reported information on factors that may influence SERT occupancy. The hyperbolic dose-occupancy relationship may provide mechanistic insight of relevance to the limited clinical benefit of dose-escalation in antidepressant treatment and the potential emergence of withdrawal symptoms. The evidence is limited by non-transparent reporting, lack of standardized methods, small sample sizes, and short treatment duration. Future studies should standardize the imaging and reporting procedures, measure occupancy at lower antidepressant doses, and investigate the moderators of the dose-occupancy relationship.
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- Academic publications [243984]
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- Faculty of Medical Sciences [92811]
- Open Access publications [104973]
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