Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades
Publication year
2022Source
Frontiers in Pediatrics, 10, (2022), article 856630ISSN
Publication type
Article / Letter to editor

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Organization
Urology
Paediatrics
Journal title
Frontiers in Pediatrics
Volume
vol. 10
Subject
Radboudumc 10: Reconstructive and regenerative medicine RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 11: Renal disorders RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Worldwide, over 1,300 pediatric kidney transplantations are performed every year. Since the first transplantation in 1959, healthcare has evolved dramatically. Pre-emptive transplantations with grafts from living donors have become more common. Despite a subsequent improvement in graft survival, there are still challenges to face. This study attempts to summarize how our understanding of pediatric kidney transplantation has developed and improved since its beginnings, whilst also highlighting those areas where future research should concentrate in order to help resolve as yet unanswered questions. Existing literature was compared to our own data of 411 single-center pediatric kidney transplantations between 1968 and 2020, in order to find discrepancies and allow identification of future challenges. Important issues for future care are innovations in immunosuppressive medication, improving medication adherence, careful donor selection with regard to characteristics of both donor and recipient, improvement of surgical techniques and increased attention for lower urinary tract dysfunction and voiding behavior in all patients.
This item appears in the following Collection(s)
- Academic publications [204951]
- Electronic publications [103216]
- Faculty of Medical Sciences [81049]
- Open Access publications [71771]
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