Lesion-symptom mapping: From single cases to the human disconnectome
Oxford : Elsevier
InDella Sala, S. (ed.), Encyclopedia of behavioral neuroscience (2nd ed.), pp. 142-154
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Della Sala, S.
SW OZ DCC PL
Della Sala, S. (ed.), Encyclopedia of behavioral neuroscience (2nd ed.)
Lesion symptom mapping has revolutionized our understanding of the functioning of the human brain. Associating damaged voxels in the brain with loss of function has created a map of the brain that identifies critical areas. While these methods have significantly advanced our understanding, recent improvements have identified the need for multivariate and multimodal methods to map hidden lesions and damage to white matter networks beyond the lesion voxels. This article reviews the evolution of lesion-symptom mapping from single case studies to the human disconnectome.
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