Hippocampal-Medial Prefrontal Event Segmentation and Integration Contribute to Episodic Memory Formation
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Publication year
2022Source
Cerebral Cortex, 32, 5, (2022), pp. 949-969ISSN
Publication type
Article / Letter to editor
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Organization
Human Genetics
Cognitive Neuroscience
PI Group Memory & Emotion
Journal title
Cerebral Cortex
Volume
vol. 32
Issue
iss. 5
Page start
p. 949
Page end
p. 969
Subject
130 000 Cognitive Neurology & Memory; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience; Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience; Cognitive Neuroscience - Radboud University Medical CenterAbstract
How do we encode our continuous life experiences for later retrieval? Theories of event segmentation and integration suggest that the hippocampus binds separately represented events into an ordered narrative. Using a functional Magnetic Resonance Imaging (fMRI) movie watching-recall dataset, we quantified two types of neural similarities (i.e., "activation pattern" similarity and within-region voxel-based "connectivity pattern" similarity) between separate events during movie watching and related them to subsequent retrieval of events as well as retrieval of sequential order. We demonstrated that compared with forgotten events, successfully remembered events were associated with distinct "activation patterns" in the hippocampus and medial prefrontal cortex. In contrast, similar "connectivity pattern" between events were associated with memory formation and were also relevant for retaining events in the correct order. We applied the same approaches to an independent movie watching fMRI dataset as validation and highlighted again the role of hippocampal activation pattern and connectivity pattern in memory formation. We propose that distinct activation patterns represent neural segmentation of events, while similar connectivity patterns encode context information and, therefore, integrate events into a narrative. Our results provide novel evidence for the role of hippocampal-medial prefrontal event segmentation and integration in episodic memory formation of real-life experience.
This item appears in the following Collection(s)
- Academic publications [245262]
- Donders Centre for Cognitive Neuroimaging [4022]
- Electronic publications [132642]
- Faculty of Medical Sciences [93207]
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