Decisional Conflict after Deciding on Potential Participation in Early Phase Clinical Cancer Trials: Dependent on Global Health Status, Satisfaction with Communication, and Timing
Publication year
2022Source
Cancers, 14, 6, (2022), article 1500ISSN
Publication type
Article / Letter to editor
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Organization
Primary and Community Care
Anesthesiology
Journal title
Cancers
Volume
vol. 14
Issue
iss. 6
Subject
Radboudumc 18: Healthcare improvement science RIHS: Radboud Institute for Health Sciences; Anesthesiology - Radboud University Medical Center; Primary and Community Care - Radboud University Medical CenterAbstract
When standard treatment options are not available anymore, patients with advanced cancer may participate in early phase clinical trials. Improving this complex decision-making process may improve their quality of life. Therefore, this prospective multicenter study with questionnaires untangles several contributing factors to decisional conflict (which reflects the quality of decision-making) in patients with advanced cancer who recently decided upon early phase clinical trial participation (phase I or I/II). We hypothesized that health-related quality of life, health literacy, sense of hope, satisfaction with the consultation, timing of the decision, and the decision explain decisional conflict. Mean decisional conflict in 116 patients was 30.0 (SD = 16.9). Multivariate regression analysis showed that less decisional conflict was reported by patients with better global health status (β = -0.185, p = 0.018), higher satisfaction (β = -0.246, p = 0.002), and who made the decision before (β = -0.543, p < 0.001) or within a week after the consultation (β = -0.427, p < 0.001). These variables explained 37% of the variance in decisional conflict. Healthcare professionals should realize that patients with lower global health status and who need more time to decide may require additional support. Although altering such patient intrinsic characteristics is difficult, oncologists can impact the satisfaction with the consultation. Future research should verify whether effective patient-centered communication could prevent decisional conflict.
This item appears in the following Collection(s)
- Academic publications [245350]
- Electronic publications [132838]
- Faculty of Medical Sciences [93207]
- Open Access publications [106383]
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