Neisseria meningitidis Serogroup Z Meningitis in a Child With Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine
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Publication year
2021Source
Pediatric Infectious Disease Journal, 40, 11, (2021), pp. 1019-1022ISSN
Publication type
Article / Letter to editor
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Organization
Paediatrics
Medical Microbiology
Laboratory Medicine
Journal title
Pediatric Infectious Disease Journal
Volume
vol. 40
Issue
iss. 11
Page start
p. 1019
Page end
p. 1022
Subject
Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences; Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences; Laboratory Medicine - Radboud University Medical Center; Medical Microbiology - Radboud University Medical Center; Paediatrics - Radboud University Medical CenterAbstract
Complement deficient patients are susceptible to rare meningococcal serogroups. A 6-year-old girl presented with serogroup Z meningitis. This led to identification of a C8 deficiency. The MenB-4C vaccine induced cross-reactive antibodies to serogroup Z and increased in vitro opsonophagocytic killing and may thus protect complement deficient patients.
This item appears in the following Collection(s)
- Academic publications [243399]
- Electronic publications [129941]
- Faculty of Medical Sciences [92493]
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