Intra-individual differences in the effect of endurance versus resistance training on vascular function: A cross-over study.
Publication year
2021Source
Scandinavian Journal of Medicine & Science in Sports, 31, 8, (2021), pp. 1683-1692ISSN
Annotation
01 augustus 2021
Publication type
Article / Letter to editor
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Organization
Radboudumc Extern
Physiology
Journal title
Scandinavian Journal of Medicine & Science in Sports
Volume
vol. 31
Issue
iss. 8
Page start
p. 1683
Page end
p. 1692
Subject
Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences; Physiology - Radboud University Medical CenterAbstract
We used a within-subject, cross-over design study to compare the impact of 4-weeks' resistance (RT) versus endurance (END) training on vascular function. We subsequently explored the association of intra-individual effects of RT versus END on vascular function with a single nucleotide polymorphism (SNP) of the NOS3 gene. Thirty-five healthy males (21 ± 2 years old) were genotyped for the NOS3 rs2070744 SNP and completed both training modalities. Participants completed 12 sessions over a 4-week period, either RT (leg-extension) or END (cycling) training in a randomized, balanced cross-over design with a 3-week washout period. Participants performed peak oxygen uptake (peak VO(2) ) and leg-extension single-repetition maximum (1-RM) testing, and vascular function assessment using flow-mediated dilation (FMD) on 3 separated days pre/post-training. Peak VO(2) increased after END (p < 0.001), while 1-RM increased after RT (p < 0.001). FMD improved after 4-weeks' training (time effect: p = 0.006), with no difference between exercise modalities (interaction effect: p = 0.92). No relation was found between individual changes (delta, pre-post) in FMD to both types of training (R(2) = 0.06, p = 0.14). Intra-individual changes in FMD following END and RT were associated with the NOS3 SNP, with TT homozygotes significantly favoring only END (p = 0.016) and TC/CC tending to favor RT only (p = 0.056). Although both training modes improved vascular function, significant intra-individual variation in the adaptation of FMD was found. The association with NOS3 genotype suggests a genetic predisposition to FMD adapting to a specific mode of chronic exercise. This study therefore provides novel evidence for personalized exercise training to optimize vascular health.
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- Academic publications [243859]
- Electronic publications [130593]
- Faculty of Medical Sciences [92795]
- Open Access publications [104904]
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