Impact of early candidemia on the long-term outcome of allogeneic hematopoietic stem cell transplant in non-leukemic patients: an outcome analysis on behalf of IDWP-EBMT
Publication year
2021Author(s)
Source
Bone Marrow Transplantation, 56, 7, (2021), pp. 1563-1572ISSN
Publication type
Article / Letter to editor
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Organization
Haematology
Journal title
Bone Marrow Transplantation
Volume
vol. 56
Issue
iss. 7
Page start
p. 1563
Page end
p. 1572
Subject
Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences; Haematology - Radboud University Medical CenterAbstract
We assessed the incidence and outcome of early candidemia after hematopoietic stem cell transplant (HSCT). The analysis included all first HSCTs performed from 2000 to 2015 in adult and pediatric patients with a non-leukemic disease and recorded in the EBMT registry. Overall survival (OS), non-relapse mortality (NRM), and relapse mortality (RM) were evaluated. Candidemia was diagnosed in 420 of 49,852 patients at a median time of 17 days post HSCT (range 0-100), the cumulative incidence being 0.85%. In 65.5% of episodes, candidemia occurred by day 30 after HSCT. The mortality rate by day 7 was 6.2%, whereas 100-day NRM was higher (HR 3.47, p < 0.0001), and 100-day OS was lower (HR 3.22, p < 0.0001) than that of patients without candidemia. After a median follow-up of 4.3 years, 5-year OS, NRM, and RM for patients with and without candidemia were 50.5% vs. 60.8%, p < 0.0001, 28.2% vs.18.8%, p < 0.0001, and 25.3% vs. 27.2%, p = 0.4, respectively. In conclusion, in non-leukemic transplant patients, the occurrence of an early episode of candidemia is rare but it is still associated with a negative effect on the outcome.
This item appears in the following Collection(s)
- Academic publications [246764]
- Faculty of Medical Sciences [93461]
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