The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder
Publication year
2021Source
International Journal of Cancer, 148, 4, (2021), pp. 981-987ISSN
Publication type
Article / Letter to editor

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Organization
Urology
Journal title
International Journal of Cancer
Volume
vol. 148
Issue
iss. 4
Page start
p. 981
Page end
p. 987
Subject
Radboudumc 15: Urological cancers RIMLS: Radboud Institute for Molecular Life SciencesAbstract
The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed targeted DNA sequencing of a panel of 41 genes on matched normal and tumor tissue of 15 primary UTUC patients treated by RNU who later developed 19 UCBs. Based on the detected tumor-specific DNA aberrations, the paired UTUC and UCB(s) of 11 patients (73.3%) showed a clonal relation, whereas in four patients the molecular results did not indicate a clear clonal relationship. Our results support the hypothesis that UCBs following a primary surgically resected UTUC are predominantly clonally derived recurrences and not separate entities.
This item appears in the following Collection(s)
- Academic publications [204980]
- Electronic publications [103240]
- Faculty of Medical Sciences [81051]
- Open Access publications [71779]
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