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      Large- and multi-scale networks in the rodent brain during novelty exploration

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      Creators
      Cohen, Michael X.
      Englitz, B.
      França, A.S.C.
      Date of Archiving
      2021
      Archive
      Radboud Data Repository
      DOI
      https://doi.org/10.34973/97he-mp85
      Related publications
      Large- and multi-scale networks in the rodent brain during novelty exploration  
      Publication type
      Dataset
      Access level
      Restricted access
      Please use this identifier to cite or link to this item: https://hdl.handle.net/2066/232582   https://hdl.handle.net/2066/232582
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      Organization
      Neuroinformatics
      Cognitive Neuroscience
      Neurophysiology
      Audience(s)
      Life sciences
      Languages used
      English
      Key words
      Synchronization; LFP; Oscillations
      Abstract
      Neural activity is coordinated across multiple spatial and temporal scales, and these patterns of coordination are implicated in both healthy and impaired cognitive operations. However, empirical cross-scale investigations are relatively infrequent, due to limited data availability and to the difficulty of analyzing rich multivariate datasets. Here we applied frequency-resolved multivariate source-separation analyses to characterize a large-scale dataset comprising spiking and local field potential activity recorded simultaneously in three brain regions (prefrontal cortex, parietal cortex, hippocampus) in freely-moving mice. We identified a constellation of multidimensional, inter-regional networks across a range of frequencies (2-200 Hz). These networks were reproducible within animals across different recording sessions, but varied across different animals, suggesting individual variability in network architecture. The theta band (~4-10 Hz) networks had several prominent features, including roughly equal contribution from all regions and strong inter-network synchronization. Overall, these findings demonstrate a multidimensional landscape of large-scale functional activations of cortical networks operating across multiple spatial, spectral, and temporal scales during open-field exploration.
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      • Datasets [1269]
      • Faculty of Medical Sciences [80459]
      • Faculty of Science [32153]
       
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