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Publication year
2021Source
Arteriosclerosis, Thrombosis, and Vascular Biology, 41, 1, (2021), pp. 62-69ISSN
Publication type
Article / Letter to editor

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Organization
Internal Medicine
Journal title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume
vol. 41
Issue
iss. 1
Page start
p. 62
Page end
p. 69
Subject
Radboudumc 16: Vascular damage RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Atherosclerosis is characterized by incessant inflammation in the arterial wall in which monocytes and macrophages play a crucial role. During the past few years, it has been reported that cells from the innate immune system can develop a long-lasting proinflammatory phenotype after brief stimulation not only with microbial products but also endogenous atherogenic stimuli. This persistent hyperactivation of the innate immune system is termed trained immunity and can contribute to the pathophysiology of atherosclerosis. Trained immunity is mediated via epigenetic and metabolic reprogramming and occurs both in mature innate immune cells as well as their bone marrow progenitors. In addition to monocytes, other innate immune and nonimmune cells involved in different stages of atherosclerosis can develop comparable memory characteristics. This mechanism provides exciting novel pharmacological targets that can be used to prevent or treat cardiovascular diseases.
This item appears in the following Collection(s)
- Academic publications [204980]
- Electronic publications [103240]
- Faculty of Medical Sciences [81051]
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