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Publication year
2021Source
Medicine and Science in Sports and Exercise, 53, 2, (2021), pp. 341-350ISSN
Publication type
Article / Letter to editor
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Organization
Physiology
PI Group Memory & Emotion
Biochemistry (UMC)
Internal Medicine
Geriatrics
Neurology
Journal title
Medicine and Science in Sports and Exercise
Volume
vol. 53
Issue
iss. 2
Page start
p. 341
Page end
p. 350
Subject
130 000 Cognitive Neurology & Memory; Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences; Radboudumc 1: Alzheimer`s disease DCMN: Donders Center for Medical Neuroscience; Radboudumc 6: Metabolic Disorders RIHS: Radboud Institute for Health Sciences; Radboudumc 6: Metabolic Disorders RIMLS: Radboud Institute for Molecular Life Sciences; Biochemistry - Radboud University Medical Center; Internal Medicine - Radboud University Medical Center; Physiology - Radboud University Medical CenterAbstract
PURPOSE: Sedentary behavior increases the risk for cardiovascular and cerebrovascular disease. To understand potential benefits and underlying mechanisms, we examined the acute and long-term impact of reduced sitting-intervention on vascular and cerebrovascular function. METHODS: This prospective study included 24 individuals with increased cardiovascular risk (65±5 years, 29.8±3.9 kg/m). Before and after 16-week reduced sitting, using a mobile-Health device with vibrotactile feedback, we examined: i. vascular function (flow-mediated dilation (FMD)), ii. cerebral blood flow (CBFv, transcranial Doppler), and iii. cerebrovascular function (cerebral autoregulation (CA) and cerebral vasomotor reactivity (CVMR)). To better understand potential underlying mechanisms, before and after intervention, we evaluated the effects of 3-hour sitting with and without light-intensity physical activity breaks (every 30-minutes). RESULTS: The first wave of participants showed no change in sedentary time (n=9, 10.3±0.5 to 10.2±0.5 hours/day, P=0.87). Upon intervention optimization by participants' feedback, the subsequent participants (n=15) decreased sedentary time (10.2±0.4 to 9.2±0.3 hours/day, P<0.01). This resulted in significant increases in FMD (3.1±0.3 to 3.8±0.4%, P=0.02) and CBFv (48.4±2.6 to 51.4.±2.6 cm/s, P=0.02), without altering CA or CVMR. Before and after the 16-week intervention, 3-hour exposure to uninterrupted sitting decreased FMD and CBFv, whereas physical activity breaks prevented a decrease (both P<0.05). CA and CVMR did not change (P>0.20). CONCLUSION: Long-term reduction in sedentary behavior improves peripheral vascular function and cerebral blood flow, and acutely prevents impaired vascular function and decreased cerebral blood flow. These results highlight the potential benefits of reducing sedentary behavior to acutely and chronically improve cardio-/cerebrovascular risk.
This item appears in the following Collection(s)
- Academic publications [245131]
- Donders Centre for Cognitive Neuroimaging [4021]
- Electronic publications [132467]
- Faculty of Medical Sciences [93207]
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