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      Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration

      Creators
      Preisig, B.P.
      Riecke, L.
      Sjerps, M.J.
      Kösem, A.V.M.
      Kop, B.R.
      Bramson, B.P.
      Hagoort, P.
      Hervais-Adelman, A.
      Date of Archiving
      2021
      Archive
      Radboud Data Repository
      DOI
      https://doi.org/10.34973/dt33-sj34
      Related publications
      Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration  
      Publication type
      Dataset
      Access level
      Restricted access
      Please use this identifier to cite or link to this item: https://hdl.handle.net/2066/230476   https://hdl.handle.net/2066/230476
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      Organization
      PI Group Neurobiology of Language
      SW OZ DCC SMN
      PI Group Affective Neuroscience
      SW OZ DCC PL
      Audience(s)
      Life sciences
      Languages used
      English
      Key words
      dichotic listening; fMRI; dynamic causal modeling; speech perception; transcranial alternating current stimulation
      Abstract
      Brain connectivity plays a major role in the encoding, transfer, and integration of sensory information. Interregional synchronization of neural oscillations in the γ-frequency band has been suggested as a key mechanism underlying perceptual integration. In a recent study, we found evidence for this hypothesis showing that the modulation of interhemispheric oscillatory synchrony by means of bihemispheric high-density transcranial alternating current stimulation (HD-TACS) affects binaural integration of dichotic acoustic features. Here, we aimed to establish a direct link between oscillatory synchrony, effective brain connectivity, and binaural integration. We experimentally manipulated oscillatory synchrony (using bihemispheric γ-TACS with different interhemispheric phase lags) and assessed the effect on effective brain connectivity and binaural integration (as measured with functional MRI and a dichotic listening task, respectively). We found that TACS reduced intrahemispheric connectivity within the auditory cortices and antiphase (interhemispheric phase lag 180°) TACS modulated connectivity between the two auditory cortices. Importantly, the changes in intra- and interhemispheric connectivity induced by TACS were correlated with changes in perceptual integration. Our results indicate that γ-band synchronization between the two auditory cortices plays a functional role in binaural integration, supporting the proposed role of interregional oscillatory synchrony in perceptual integration.
      This item appears in the following Collection(s)
      • Datasets [1528]
      • Donders Centre for Cognitive Neuroimaging [3762]
      • Faculty of Social Sciences [29098]
       
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