The Personalized Parkinson Project: examining disease progression through broad biomarkers in early Parkinson’s disease
Publication year
2019Source
BMC Neurology, 19, 1, (2019), article 160ISSN
Publication type
Article / Letter to editor

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Organization
Neurology
Laboratory Medicine
PI Group Systems Neurology
Health Evidence
IQ Healthcare
Journal title
BMC Neurology
Volume
vol. 19
Issue
iss. 1
Subject
240 Systems Neurology; Radboudumc 17: Women's cancers RIHS: Radboud Institute for Health Sciences; Radboudumc 18: Healthcare improvement science RIHS: Radboud Institute for Health Sciences; Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical NeuroscienceAbstract
Our understanding of the etiology, pathophysiology, phenotypic diversity, and progression of Parkinson’s disease has stagnated. Consequently, patients do not receive the best care, leading to unnecessary disability, and to mounting costs for society. The Personalized Parkinson Project (PPP) proposes an unbiased approach to biomarker development with multiple biomarkers measured longitudinally. Our main aims are: (a) to perform a set of hypothesis-driven analyses on the comprehensive dataset, correlating established and novel biomarkers to the rate of disease progression and to treatment response; and (b) to create a widely accessible dataset for discovery of novel biomarkers and new targets for therapeutic interventions in Parkinson’s disease.
This item appears in the following Collection(s)
- Academic publications [203856]
- Donders Centre for Cognitive Neuroimaging [3391]
- Electronic publications [102283]
- Faculty of Medical Sciences [80326]
- Open Access publications [70939]
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