Impact of rescanning and normalization on convolutional neural network performance in multi-center, whole-slide classification of prostate cancer
SourceScientific Reports, 10, 1, (2020), article 14398
Article / Letter to editor
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SubjectRadboudumc 15: Urological cancers RIHS: Radboud Institute for Health Sciences; Radboudumc 17: Women's cancers RIHS: Radboud Institute for Health Sciences
Algorithms can improve the objectivity and efficiency of histopathologic slide analysis. In this paper, we investigated the impact of scanning systems (scanners) and cycle-GAN-based normalization on algorithm performance, by comparing different deep learning models to automatically detect prostate cancer in whole-slide images. Specifically, we compare U-Net, DenseNet and EfficientNet. Models were developed on a multi-center cohort with 582 WSIs and subsequently evaluated on two independent test sets including 85 and 50 WSIs, respectively, to show the robustness of the proposed method to differing staining protocols and scanner types. We also investigated the application of normalization as a pre-processing step by two techniques, the whole-slide image color standardizer (WSICS) algorithm, and a cycle-GAN based method. For the two independent datasets we obtained an AUC of 0.92 and 0.83 respectively. After rescanning the AUC improves to 0.91/0.88 and after style normalization to 0.98/0.97. In the future our algorithm could be used to automatically pre-screen prostate biopsies to alleviate the workload of pathologists.
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