Functional complaints and quality of life after transanal total mesorectal excision: a meta-analysis
Publication year
2020Source
British Journal of Surgery, 107, 5, (2020), pp. 489-498ISSN
Publication type
Article / Letter to editor

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Organization
Surgery
Journal title
British Journal of Surgery
Volume
vol. 107
Issue
iss. 5
Page start
p. 489
Page end
p. 498
Subject
Radboudumc 14: Tumours of the digestive tract RIHS: Radboud Institute for Health SciencesAbstract
BACKGROUND: Total mesorectal excision (TME) gives excellent oncological results in rectal cancer treatment, but patients may experience functional problems. A novel approach to performing TME is by single-port transanal minimally invasive surgery. This systematic review evaluated the functional outcomes and quality of life after transanal and laparoscopic TME. METHODS: A comprehensive search in PubMed, the Cochrane Library, Embase and the trial registers was conducted in May 2019. PRISMA guidelines were used. Data for meta-analysis were pooled using a random-effects model. RESULTS: A total of 11 660 studies were identified, from which 14 studies and six conference abstracts involving 846 patients (599 transanal TME, 247 laparoscopic TME) were included. A substantial number of patients experienced functional problems consistent with low anterior resection syndrome (LARS). Meta-analysis found no significant difference in major LARS between the two approaches (risk ratio 1·13, 95 per cent c.i. 0·94 to 1·35; P = 0·18). However, major heterogeneity was present in the studies together with poor reporting of functional baseline assessment. CONCLUSION: No differences in function were observed between transanal and laparoscopic TME.
This item appears in the following Collection(s)
- Academic publications [203686]
- Electronic publications [102078]
- Faculty of Medical Sciences [80280]
- Open Access publications [70775]
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