Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr(-/-) .Leiden mice
Publication year
2020Source
The Faseb Journal, 34, 7, (2020), pp. 9575-9593ISSN
Publication type
Article / Letter to editor

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Organization
Medical Imaging
Neurology
Cognitive Neuroscience
Journal title
The Faseb Journal
Volume
vol. 34
Issue
iss. 7
Page start
p. 9575
Page end
p. 9593
Subject
Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience; Radboudumc 1: Alzheimer`s disease DCMN: Donders Center for Medical NeuroscienceAbstract
The obesity epidemic increases the interest to elucidate impact of short-chain fatty acids on metabolism, obesity, and the brain. We investigated the effects of propionic acid (PA) and caproic acid (CA) on metabolic risk factors, liver and adipose tissue pathology, brain function, structure (by MRI), and gene expression, during obesity development in Ldlr(-/-) .Leiden mice. Ldlr(-/-) .Leiden mice received 16 weeks either a high-fat diet (HFD) to induce obesity, or chow as reference group. Next, obese HFD-fed mice were treated 12 weeks with (a) HFD + CA (CA), (b) HFD + PA (PA), or (c) a HFD-control group. PA reduced the body weight and systolic blood pressure, lowered fasting insulin levels, and reduced HFD-induced liver macrovesicular steatosis, hypertrophy, inflammation, and collagen content. PA increased the amount of glucose transporter type 1-positive cerebral blood vessels, reverted cerebral vasoreactivity, and HFD-induced effects in microstructural gray and white matter integrity of optic tract, and somatosensory and visual cortex. PA and CA also reverted HFD-induced effects in functional connectivity between visual and auditory cortex. However, PA mice were more anxious in open field, and showed reduced activity of synaptogenesis and glutamate regulators in hippocampus. Therefore, PA treatment should be used with caution even though positive metabolic, (cerebro) vascular, and brain structural and functional effects were observed.
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- Academic publications [227425]
- Electronic publications [107141]
- Faculty of Medical Sciences [86157]
- Open Access publications [76286]
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