The functional and structural brain alterations in ADHD and their genetic correlates
[S.l. : s.n.]
Radboud University, 19 november 2020
Promotor : Franke, B. Co-promotores : Hoogman, M., Bralten, J.B.
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SubjectDonders Center for Medical Neuroscience; Radboudumc 7: Neurodevelopmental disorders; Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience
Attention deficit/Hyperactivity disorder (ADHD) is one of the most prevalent childhood-onset psychiatric disorders and the most commonly treated neuropsychiatric disorder. It is a heterogeneous, heritable, and multifactorial disorder. Yet the real pathogenesis of ADHD remains unclear. Therefore, the work of Zhaomin Wu aims to explore ADHD-related brain alterations, their functional consequences, and genetic underpinnings. A series of interconnected studies were combined in this thesis, ranging from a clinical randomized study, a cross-sectional case-control neuroimaging study, to a population-based study. Ultimately, her studies have demonstrated that clinically diagnosed ADHD is a complex disease with altered brain function and structure, and methylphenidate, as the first line medication, helps to normalize some of the functional brain differences in children with ADHD. The ADHD symptoms not only exist in patients but also to a certain extend in the general population.
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