Shared genetic background between children and adults with attention deficit/hyperactivity disorder

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Title:	Shared genetic background between children and adults with attention deficit/hyperactivity disorder
Author(s):	Rovira, P.; Demontis, D.; Sánchez-Mora, C.; Zayats, T.; Klein, M. ; Mota, N. ; Weber, H.; Garcia-Martínez, I.; Pagerols, M.; Vilar-Ribó, L.; Arribas, L.; Richarte, V.; Corrales, M.; Fadeuilhe, C.; Bosch, Rosa; Martin, G.E.; Almos, P.; Doyle, A.E.; Grevet, E.H.; Grimm, O.; Halmøy, A.; Hoogman, M. ; Hutz, M.; Jacob, C.P.; Kittel-Schneider, S.; Knappskog, P.M.; Lundervold, A.J.; Rivero, O.; Rovaris, D.L.; Salatino-Oliveira, A.; Silva, B.S. da; Svirin, E.; Sprooten, E. ; Strekalova, T.; Arias-Vasquez, A. ; Sonuga-Barke, E.J.; Asherson, P.; Bau, C.H.D.; Buitelaar, J.K. ; Cormand, B.; Faraone, S.V; Haavik, J.; Johansson, S.E.; Kuntsi, J.; Larsson, H.; Lesch, K.P.; Reif, A.; Rohde, L.A.; Casas, M.; Børglum, A.D.; Franke, B. ; Ramos-Quiroga, J.A.; Artigas, M. Soler; Ribasés, M.
Publication year:	2020
Source:	Neuropsychopharmacology (New York), vol. 45, iss. 10, (2020), pp. 1617-1626
ISSN:	0893-133X
DOI:	https://doi.org/10.1038/s41386-020-0664-5
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/225384
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Subject:	220 Statistical Imaging Neuroscience Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience
Organization:	Human Genetics Psychiatry PI Group Statistical Imaging Neuroscience Cognitive Neuroscience PI Group Memory and Emotion
Journal title:	Neuropsychopharmacology (New York)
Volume:	vol. 45
Issue:	iss. 10
Page start:	p. 1617
Page end:	p. 1626
Abstract:	Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.