Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring
Publication year
2020Source
AIDS Research and Therapy, 17, 1, (2020), article 57ISSN
Publication type
Article / Letter to editor

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Organization
Radboudumc Extern
Clinical Pharmacy
Journal title
AIDS Research and Therapy
Volume
vol. 17
Issue
iss. 1
Subject
Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health SciencesAbstract
Real-time medication monitoring (RTMM) may potentially enhance adherence to antiretroviral treatment (ART). We describe a participant in an ongoing trial who, shortly after completing trial participation, died of cryptococcal meningitis despite high levels of adherence according to self-report, pill-counts and RTMM (> 99%). However, she evidenced consistently high HIV viral load throughout the 48-week study follow-up. Subsequently, her relatives unsolicitedly returned eight months' dispensed ART medication that she was supposed to have taken. This brief report illustrates the challenges of adherence measurements including RTMM, and reinforces the need to combine adherence assessments with viral load monitoring in HIV care.
This item appears in the following Collection(s)
- Academic publications [227436]
- Electronic publications [107269]
- Faculty of Medical Sciences [86157]
- Open Access publications [76399]
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