Clusters of Tolerogenic B Cells Feature in the Dynamic Immunological Landscape of the Pregnant Uterus
Publication year
2020Source
Cell Reports, 32, 13, (2020), article 108204ISSN
Publication type
Article / Letter to editor

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Organization
Paediatrics
Laboratory Medicine
Gynaecology
Tumorimmunology
Journal title
Cell Reports
Volume
vol. 32
Issue
iss. 13
Subject
Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 5: Inflammatory diseases RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Well-timed interaction of correctly functioning maternal immune cells is essential to facilitate healthy placenta formation, because the uterine immune environment has to tolerate the semi-allogeneic fetus and allow adequate trophoblast invasion. Here, we assess the uterine immune signature before and during pregnancy. Extensive supervised and unsupervised flow cytometry clustering strategies not only show a general increase in immune memory throughout pregnancy but also reveal the continuous presence of B cells. Contrary to the belief that B cells are merely a consequence of uterine pathology, decidual B cells produce IL-10 and are found to be localized in clusters, together with Foxp3(pos) T cells. Our findings therefore suggest a role for B cells in healthy pregnancy.
This item appears in the following Collection(s)
- Academic publications [227727]
- Electronic publications [107315]
- Faculty of Medical Sciences [86204]
- Open Access publications [76446]
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