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Publication year
2000Source
Cell Death and Differentiation, 7, 7, (2000), pp. 616-27ISSN
Publication type
Article / Letter to editor

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Organization
Biomolecular Chemistry
Journal title
Cell Death and Differentiation
Volume
vol. 7
Issue
iss. 7
Page start
p. 616
Page end
p. 27
Subject
Bio-Molecular ChemistryAbstract
Autoimmune diseases are frequently characterized by the presence of autoantibodies directed against nucleic acid-protein complexes present in the nucleus of the cell. The mechanisms by which these autoantigenic molecules escape immunological tolerance are largely unknown, although a number of recent observations suggest that modified self-proteins generated during apoptosis may play an important role in the development of autoimmunity. It has been hypothesized that the recognition of these modified self-proteins by the immune system may promote autoantibody production. While apoptosis is specifically characterized by posttranslational modification of proteins, recent findings also show that nucleic acids are modified. This review summarizes the specific cleavages of some of these key nucleic acids, i.e. chromosomal DNA, ribosomal RNA and small structural RNAs (U1 snRNA, Y RNA), in apoptotic cells.
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- Faculty of Science [34316]
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