Publication year
2002Source
Hormone and Metabolic Research, 34, 4, (2002), pp. 182-5ISSN
Publication type
Article / Letter to editor
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Organization
Physiology
Pharmacology-Toxicology
Journal title
Hormone and Metabolic Research
Volume
vol. 34
Issue
iss. 4
Page start
p. 182
Page end
p. 5
Subject
Bloodpressure regulation, tissue oxygenation and exercise; Effects and kinetics of drugs in kidney and blood vessels; Hypertension and Circulation; Bloeddrukregulatie, weefseloxygenatie en inspanning; Effecten en lotgevallen van geneesmiddelen in nier en bloedvaten; Hypertensie en circulatieAbstract
The biguanide, metformin, is widely used for the treatment of type 2 diabetes mellitus. In the recently published United Kingdom Prospective Diabetes Study (UKPDS), it was shown that the use of metformin was associated with a reduction of macrovascular complications compared to other blood glucose-lowering strategies. The present study was aimed at determining whether metformin has direct beneficial effects on the heart. We tested the effects of metformin on cardiac functional recovery after a mild ischemic incident (stunning) in our isolated, erythrocyte perfused, rat working-heart model. Three groups were tested: vehicle, 50 and 500 micromol/l metformin (total n = 6). In diabetic rats, a concentration of 50 microM has been shown to reduce the blood glucose concentration. Slight metformin-induced increases in coronary blood flow during normoxia (pre-ischemically) and during reperfusion (post-ischemically) were observed and compared to vehicle (p < 0.05). Both metformin concentrations significantly reduced cardiac functional loss induced by the 12-min global ischemic incident compared with vehicle (3.4 +/- 1.0 % and 3.5 +/- 0.6 % loss during metformin versus 10.7 +/- 0.8 % during vehicle, p < 0.001). This study clearly shows that metformin acutely improves cardiac function after a mild ischemic incident (stunning) in rats.
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