Familial oligoasthenoteratozoospermia: evidence of autosomal dominant inheritance with sex-limited expression.
SourceFertility and Sterility, 77, 2, (2002), pp. 415-418
Article / Letter to editor
Display more detailsDisplay less details
Fertility and Sterility
SubjectChromosomal aberrations and cancer; Elucidation of hereditary disorders and their molecular diagnosis; Prevention of disorders in human reproduction: (Patho)Physiological, endocrinological and methabolic aspects; Chromosomale aberraties en kanker; Opheldering van erfelijke ziekten en hun moleculaire diagnostiek; Preventie van stoornissen in de menselijke voortplanting: (Patho-)fysiologische, endocriene en metabole aspecten.
OBJECTIVE: To report the familial occurrence of severe oligoasthenoteratozoospermia in a man and five male relatives related through their mothers. DESIGN: Case report. SETTING: University medical center. PATIENT(S): Six affected family members. MAIN OUTCOME MEASURE(S): Blood and semen samples were collected from all affected males and some of their healthy male relatives. Pedigree analysis and exclusion of X-linked disorder were done. RESULT(S): Analysis suggested that familial nonsyndromic male factor infertility was present. CONCLUSION(S): The family described in this report suggests the existence of an autosomal dominant trait of male infertility with sex-limited expression.
Upload full text
Use your RU credentials (u/z-number and password) tolog in with SURFconextto upload a file for processing by the repository team.