Estimating intra-axonal axial diffusivity with diffusion MRI in the presence of fibre orientation dispersion
Concord, CA : International Society for Magnetic Resonance in Medicine (ISMRM)
InProceedings of the 28th Annual Meeting of the ISMRM, pp. 1-9
28th Annual Meeting of the International Society for Magnetic Resonance in Medicine (Paris, France, 8-13 August)
Article in monograph or in proceedings
Display more detailsDisplay less details
SW OZ DCC SMN
Proceedings of the 28th Annual Meeting of the ISMRM
SubjectAction, intention, and motor control
Intra-axonal axial diffusivity could be interesting biomarker of disease, yet it is often assumed constant across the white matter. Furthermore, when intra-axonal diffusivity is estimated, few models account for fibre orientation dispersion which (when not explicitly modelled) will greatly affect the estimates of axial diffusion. Here we combine the stick model of intra-axonal diffusion with a simple model of fibre dispersion to simultaneously estimate intra-axonal axial diffusivity and fibre dispersion on a voxel-wise basis in high b-value data. Our results demonstrate considerable variability in the intra-axonal axial diffusivity across the white matter.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.