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      THE COGNITIVE EFFECTS OF A PROMISED BONUS DO NOT DEPEND ON DOPAMINE SYNTHESIS CAPACITY

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      Creators
      Hofmans, L.
      Bosch, R. van den
      Määttä, J.I.M.
      Verkes, Robbert-Jan
      Aarts, E.
      Cools, R.
      Date of Archiving
      2020
      Archive
      Radboud Data Repository
      DOI
      https://doi.org/10.34973/s0fm-3e10
      Publication type
      Dataset
      Access level
      Restricted access
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      Organization
      Psychiatry
      PI Group Motivational & Cognitive Control
      Onderzoekcentrum voor Staat en Recht
      Audience(s)
      Life sciences
      Languages used
      English
      Key words
      dopamine, synthesis capacity, striatum, cognitive control, Stroop, replication;
      Abstract
      Reward motivation is known to enhance cognitive control. However, detrimental effects have also been observed, which have been attributed to overdosing of already high baseline dopamine levels by further dopamine increases elicited by reward cues. Aarts et al. (2014) indeed demonstrated, in 14 individuals, that reward effects depended on striatal dopamine synthesis capacity, measured with [18F]FMT-PET: promised reward improved Stroop control in low-dopamine individuals, while impairing it in high-dopamine individuals. Here, we aimed to assess this same effect in 44 new participants, who had previously undergone an [18F]DOPA-PET scan to quantify dopamine synthesis capacity. This sample performed the exact same rewarded Stroop paradigm as in the prior study. However, we did not find any correlation between reward effects on cognitive control and striatal dopamine synthesis capacity. Critical differences between the radiotracers [18F]DOPA and [18F]FMT are discussed, as the discrepancy between the current and our previous findings might reflect the use of the potentially less sensitive [18F]DOPA radiotracer in the current study.
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      • Datasets [816]
      • Donders Centre for Cognitive Neuroimaging [2967]
      • Faculty of Law [18101]
      • Faculty of Medical Sciences [74529]
       
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